We will review and present new results regarding “no-go” theorems for four-dimensional de Sitter solutions in the Heterotic string. As a concrete means of realizing accelerating solutions in string theory, we present a construction of domain walls in string theory. The domain walls can bridge both Minkowski and AdS string vacua. A key ingredient in the construction are novel classical Yang-Mills configurations, including instantons, which interpolate between toroidal Yang-Mills vacua. Our construction provides a concrete framework for the study of inflating metrics in string theory. In some cases, the accelerating space-time comes with a holographic description. The general form of the holographic dual is a field theory with parameters that vary over space-time.