Precision calculations in de Sitter space (such as of inflationary predictions for primordial fluctuations) are often plagued by infrared problems and issues of secular time dependence. Similar issues about the breakdown of perturbation theory seem also to arise for information loss in black holes. This talk briefly summarizes how similar problems can arise in other areas of physics, and how they are dealt with when they do. It is argued that Master-Equation techniques used in areas like optics also apply to cosmology (and possibly black holes) and can tell us how to extract reliably late-time predictions. Applied to inflation they lead to Starobinsky's stochastic methods (plus small but important corrections). This is argued to provide an explanation for why stochastic inflation seems to resum IR effects in simple examples, and allows these tools to be generalized to apply more broadly. I mention in passing the relevance of these tools to the problem of Schrodinger's Cosmologist: how primordial fluctuations decohere sometime between their production during inflation and their observation early in the present Big Bang Epoch.